With the tremendous advancement around the globe, every industry is flourishing rapidly, and so is the health industry. The health researchers are trying to keep pace with the evolution to keep the population updated. Their aim is the well-being of humankind, making health products reach a maximum number of people.
One of the newest discoveries that have made its way into the market is the Cannabidiol or CBD products. The reason? More natural consumption, broader access, and ample benefits. Its high healing powers have made it the center of attraction, especially for the people who seek a cure with natural compounds.
Owing to such advantages, the manufacturers are more inclined towards producing a variety of CBD products. However, the compound is still under research, and the feedback of the consumers is of considerable significance. Their response might influence the researchers to reach an inevitable conclusion. The majority of the consumers are satisfied and seem to add the product to their routine use.
Let’s Have a Glance at the History of CBD!
Its roots go back to 2700 BC, being used as a remedy for many ailments.
It was 1838 when William B. O’Shaughnessy, an Irish researcher, investigated the effects of cannabis plants in hisstudy. After this, another study to unveil the facts about its constituents is advancements in research and technology.
In the year 1942, Roger Adams, an American chemist, was the first person to isolate cannabidiol and discover the other compound of the plant, tetrahydrocannabinol.
Later on, Dr Raphael Mechoulam was the person to lead another event in recognition of Cannabis plants. He explained the structural chemistry of the compounds, CBD and THC in 1963 and 1964, respectively.
The research era continued in the 1980s when Dr Mechoulam studied the potency of CBD to treat epilepsy. His study involved epileptic patients who were treated with a fixed dose of CBD. After a period of four months, he observed that seizures stopped in half of the patients, whereas the other half experienced a decline of seizures.
Did You Know the Difference Between CBD and THC?
A Phyto-cannabinoid known as cannabidiol or CBD- is found in the cannabis plant, either hemp or marijuana (family: Cannabaceae). The cannabis plant consists of a high amount of phyto-cannabinoids (a class of cannabinoids), among which around 113 are identified.
Other than CBD, one of the most common compounds found in the cannabis plant is THC. Tetrahydrocannabinol, abbreviated as THC, is the psychoactive compound, giving a ‘high’ sensation to its consumer. The euphoric effect linked with THC is due to its binding with CB1 receptors inside the brain.
These compounds are present in varying quantities in various cannabis plants. While Marijuana contains high levels of THC, hemp has less amount of THC. On the other hand, CBD is derived from both hemp and Marijuana. Both the compounds share the same molecular formula (C21H30O2) yet possess a slight difference in the arrangement of their atoms.
The National Center for Biotechnology Information claims CBD as a nonpsychoactive compound, whereas THC is psychoactive, thus making you high.
Have a Look at the Brief Overview of CBD Products!
The U.S. Food and Drug Administration approved the first CBD-containing medicine, named as Epidiolex, in June 2018. Hence, the CBD era started, and its industry started getting flourished.
Till now, CBD has been incorporated in a wide range of products, administered through different routes. The CBD products available in the market include creams, lotions, serums, and oil for topical applications, supplements, edibles (candies and gummies), drinks, nasal sprays, inhalers, transdermal patches, vapes, etc. Plus, there are edibles and oils available even for pets.
The consumers use the product that is best suited to their needs and ease. They might use them for healing or leisure purposes. Whatever the reason is, the aim is to receive its effects without harming the body.
In this article, we will shed a spotlight on CBD oil.
A Potent CBD-containing Product |CBD Oil
CBD oil is extracted from flowers, leaves, stalks of the plant as they contain a higher concentration of the compound.
The product has come to the spotlight for its therapeutic and recreational uses. Many randomized and controlled trials are being carried out, and its full therapeutic potential is yet to be explored. With the research going on, CBD is showing high tolerability in humans, with a few exceptions.
What Are Some of the Great Benefits You Get With CBD Oil?
CBD oil is one of the most popular and natural remedies that is used for specific ailments. It is one of over 100 chemical compounds known as cannabinoids or CBD, present in the marijuana or cannabis plant, commonly known as Cannabis sativa.
THC, also called tetrahydrocannabinol, is the primary psychoactive cannabinoid present in cannabis, which causes the sensation of getting high and is often linked with Marijuana too. Unlike THC, however, CBD is not psychoactive.
This factor makes CBD an attractive option to the ones who are seeking pain relief and other symptoms without having mind-alerting effects of Marijuana or other pharmaceutical drugs. It is made up of extracting CBD out of the cannabis plant and is then diluted with a carrier oil such as hemp seed oil or coconut oil.
However, it is attaining momentum in the wellness and health world as some of the scientific studies confirm the ease symptoms of ailments such as chronic pain along with anxiety.
Here are some of the health benefits that CBD oil serves with some scientific evidence:
1. As a Neuroprotective Agent:
According to researchers, CBD’s ability to act on the endocannabinoid system and specific brain signaling systems has particular benefits for the ones having neurological disorders. One of the great uses of CBD is for treating neurological disorders such as multiple sclerosis and Epilepsy. Although the research in this part is relatively new and certain studies have shown effective results.
CBD oil has been observed to protect the neuronal cells, preserve their function, and inhibit their death, hence plays the role to protect the nervous system from injury. Moreover, the results of several studies showed that CBD provides defense against brain injury and liver injury, too.
An oral spray called Sativex consists of CBD and THC and is proven to be an effective and safest way of reducing muscle spasticity in people with multiple sclerosis. Research is going on to discover the treatment of nervous disorders using CBD oil.
2. For Psychiatric Disorders:
Many of the people go through specific psychiatric issues and seek help from different sources. However, they end up getting addicted to some harmful medication or drugs. CBD has proven to be an effective remedy for such people as it helps in treating them efficiently.
Patients find it more tolerable than standard psychiatric treatment. However, research is in progress to obtain any evidence regarding the effects of CBD oil for mental diseases.
3. For Relieving Pain:
Back in 2900 B.C., Marijuana was used to treat pain; however, scientists have discovered that some of the components of Marijuana along with CBD, help relieve pain.
CBD possesses anti-inflammatory and analgesic properties. And its oil may affect the pain receptors found in the brain.
While It has shown its effects on pain management and inflammation, more scientific evidence is needed to prove its efficacy and safety.
CBD has neuroprotective and anti-inflammatory effects and appears to be well tolerated in humans. The human body has a specialized system known as the endocannabinoid system (ECS that is indulged in regulating a range of functions such as appetite, sleep, immune system response, and pain. Besides, the body makes endocannabinoid receptors in the nervous system too. According to some search, CBD helps in reducing chronic pain by impacting endocannabinoid receptor activity, interacting with neurotransmitters, and reducing inflammation.
For instance, a study on rats found that CBD injections help reduce pain response to surgical incision.
4. Anxiolytic and Sleep-inducing Effects:
A study conducted at the University of Colorado School of Medicine in Fort Collins has shown that CBD is helpful to control anxiety and insomnia, developed as the side effects of Post-traumatic stress disorder (PTSD). It has proven to reduce the issues mentioned above in animals too.
It induces sleep by delivering calmness and relaxation within the body. By combating pain and reducing insomnia, the oil helps to have a peaceful sleep.
A study carried out by two researchers, Jamie Corroon and Joy A. Phillips, was conducted to observe the efficacy of CBD oil. The majority of the participants used it for any medical condition; more than half reported the oil to be very useful for their requirements. It provided higher relief for chronic pain, arthritis, anxiety, depression, and insomnia. Additionally, it proved to be efficacious for some autoimmune disorders, neuropathy, and fibromyalgia.
5. For skin problems
One of the most common skin conditions affecting more than 9% of the population is acne, which is caused by bacteria, genetics, underlying inflammation, and overproduction of sebum (an oily secretion made by sebaceous glands present in the skin).
According to some scientific studies, CBD oil may help treat acne due to its anti-inflammatory factors and the ability to reduce sebum production.
Another study states that CBD can be an efficient way of treating acne. However, these results are promising, and human studies exploring these effects regarding CBD and acne are much needed.
A study was carried out to observe the effects of CBD oil on acne vulgaris. As per the conclusion, the product seems to be potential in treating acne because it inhibits excessive lipid production (hypostatic) and undesired growth of cells in sebaceous glands. It is also observed to hinder inflammation and proliferation.
One of the rare skin diseases is Epidermolysis bullosa. It is a skin disorder that forms painful blisters on the skin. Effective results were obtained when a study was performed on a group of patients with this disease. However, further well-controlled clinical trials are needed to prove the results obtained.
However, more human trials are needed to favour the potential use of CBD oil for skin disorders.
6. For Reducing Marijuana Addiction:
People across the globe are addicted to Marijuana and other addictive drugs for numbing pain or other purposes. CBD oil has all the specific qualities that help in reducing marijuana addiction along with other addictive medication.
It also helps in reducing the vomiting, nausea, and withdrawal symptoms in a particular person.
A study for the use of CBD oil to overcome marijuana addiction says that it can be beneficial to sweep over marijuana addiction. It involves reducing a person’s anxiety and insomnia.
7. Anti-cancer Effects:
CBD can help in reducing symptoms linked with cancer side effects related to cancer treatment such as vomiting, nausea, and pain. One of the studies looked into the effects of THC and CBD in 177 of the people having cancer pain who had not experienced relief with medication.
However, the ones who got treatment with an extract having both the compounds felt a significant reduction in pain compared to those who only got THC extract. CBD can also help reduce chemotherapy-induced vomiting and nausea, which are the most common side effects of chemotherapy.
It has surprisingly shown to be effective in prostate and ovarian cancer. Additionally, an animal study showed that it fights against the cancerous cells and stops their growth. However, it needs scientific evidence to prove its efficacy on the same level as of the chemotherapy.
Although they are the drugs helping with distressing symptoms, they are sometimes insufficient and lead some people to search for some alternatives.
8. For Cardiovascular Diseases (CVDs):
According to recent research, CBD has several benefits for heart and circulatory systems, so lowering high blood pressure is common. High B.P. has a more top connection with the risk of several health conditions such as heart attack, stroke, and metabolic syndrome.
As per studies, CBD can effectively help with high blood pressure and reduce anxiety and stress too.
It has cardioprotective activity and, thus, plays its role in arrhythmia by preventing ectopic beats. It has shown its effects on improving blood pressure to lessen cardiac problems-angina, stroke, and heart failure-and restore its function.
An Animal study showed how CBD was effective when administered for anti-arrhythmic activity in mice. It seemed to be useful for cardiac dysfunction and inflammation of the myocardium.
9. For Epilepsy and Seizures:
Some of the evidence from the laboratory studies, small clinical studies, and anecdotal reports over several years show that CBD can potentially help in controlling seizures and Epilepsy. Research on CBD has taken a lot of time and been hard due to federal regulations with limited access to cannabidiol.
Besides, there are specific time and financial constraints where several studies have shown the advantages of specific plant-based CBD items in treating certain groups of people with Epilepsy and seizures. They do not respond to traditional treatments and therapies.
The FDA has approved the use of CBD oil for the epilepsy-Dravet syndrome (by FDA-approved drug: Epidiolex) and Lennox-Gastaut syndrome.
10. Reducing depression and Anxiety:
Depression and anxiety are common mental health illnesses that can be devastating to a person’s well-being and health. As per WHO (world health organization), depression contributes to disability worldwide, and anxiety ranks 6th globally. Depression and anxiety are generally cured with pharmaceutical drugs that cause a variety of side effects such as drowsiness, insomnia, agitation, sexual dysfunction, and headache.
Medication such as benzodiazepines can somehow be addictive and lead to substance abuse. What can be worse than this? CBD oil helps in treating both anxiety and depression. Besides, it helps in treating insomnia and anxiety in children having post-traumatic stress disorder.
How Much Dosage of CBD Oil Should Be Taken?
For CBD, there’s no Recommended Daily Intake (RDI) given by the FDA. Hence, it can be confusing for some consumers as with what dose they should start. We recommend first that you speak to someone who has experience with taking a CBD regiment. The regiment after all is the major reason some pople feel CBD worked, whole others say it doesn’t work. Call Gurilla Regiment specialists @1.877.611.7911 and they will be more than willing to make sure that you choose the right product and A regiment to start out with. Most of the Regiment specialist have been working closely with hundreds of customers on a regular basis for years. They have first hand experience working with people so they can help guide you through this of course we hope that you use your Family doctor as-well after all they are the ones with the medical license. For those of you that haven’t seen a doctor and don’t like doctors give the regiment specialists a call and they will help you find the best way to take your
CBD products. They will also show you how to pin point the perfect amount of CBD to reach that therapeutic dose so you get the therapeutic benefits from CBD that most people do when they on the right regiment,
The exact dosage might not be easy to determine as each individual has a different experience with its use. The dosage is calculated or determined based upon factors like the person’s body parameters (age, gender, weight, body chemistry, etc.), tolerance to CBD, the condition for which it is taken, the concentration of CBD in the oil, etc.
Start with low doses and increase slowly to adjust. Your physician will guide you in this regard and will adjust your dosage accordingly. If you want the right results, you would need to observe the condition of your body right after a few initial doses. In case of any side effects, stop its use promptly and report to the doctor.
Higher or Lower Doses of CBD-Do They Have Any Effect?
According to researchers, while the higher doses of CBD might result in liver toxicity, its smaller doses for an extended period could cause swelling or damage to the liver. It is clear that until now, no study has supported the higher doses or continuous low doses.
Does CBD Oil Harm in Any Way?
No such severe side effects have been revealed by the patients who used CBD oil within the prescribed dose. But due to the presence of fewer studies, patients should be carefully advised regarding the use of CBD products. Even according to some findings, the quantities of CBD and THC are not accurately labelled on the products.
Does CBD Oil Have Any Effects on Pregnancy?
There is a need to conduct extensive research on CBD’s effects on fertility, fetal development, and breastfeeding. Safe to say that pregnant women should avoid its use until the researchers do not conclude in this regard.
A study was conducted on mice to observe the effects of CBD on pregnant animals. The CBD given to the mothers interfered with the reproductive system of fetuses (males) and caused reproductive dysfunction.
Is CBD Oil Safe for Liver and Kidney Patients?
People who are hepatic or renally-compromised should be extra cautious when taking CBD doses. Many other clinical drugs are contraindicated in liver and kidney patients. The dysfunction of these organs impacts metabolization and excretion. Let’s be hopeful that clinical trials would soon find this out!
It was observed in an animal study that CBD prevented the nephrotoxicity induced by the drug cisplatin. However, this isn’t enough to provide scientific evidence regarding renal safety with CBD use.
Are There Any Significant Interactions With CBD?
If you intend to take CBD while you’re on other medications, you should ask your physician about the safety issues. Why?
Here’s the answer:
According to a study published in 2017 by Kerstin Iffland and Franjo Grotenhermen, the concurrent administration of CBD and some other drugs can have altered effects on our body’s system. The liver enzyme CYP3A4 is responsible for metabolizing CBD, and a number of drugs inhibit the same enzyme. It explains that the co-administration of any of these drugs with CBD can result in the decreased metabolization of CBD. Consequently, its levels in the blood are raised, leading to its long residence time in the body. However, the adverse effects aren’t severe following the slight interaction. On the other hand, some drugs induce the CYP3A4 enzyme, which means that there will be a rapid degradation of CBD and lesser clinical effects.
Having read about the benefits of CBD oil, its future seems very promising. However, its scientific background isn’t yet completely evolved. And researchers are in search of its facts to develop a complete profile. Along with all its desirable features, we need to see the pitfalls associated with it, such as its undesirable effects linked to a specific age group, or a medical condition, or even its medications.
All in all, the CBD consumers have a glimmer of hope with the future of CBD products.
Meta description: CBD oil is extracted from cannabis plants. It is evolving as a cure to relieve the symptoms of common health conditions such as pain, stress, anxiety, insomnia, etc.
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